Ro4-1539 (other names: furethylnorlevorphanol, Ro4-1539 HCl) it is an opioid substance, an active agonist of the m-opioid receptors and has analgesic properties.
History
Ro4-1539 was first developed in the 1950s by Hoffmann-La Roche.
Chemistry
Ro4-1539 has a related structure with levorphanol.
Pharmacology
This substance is relatively new and there is little data on its toxicological and pharmacological properties. According to studies on rodents, it was found that this substance has excellent analgesic properties, causes sedation and euphoria, itching, constipation, can cause respiratory depression at high dosages and can be addictive with prolonged use. Ro4-1539 is 30-60 times stronger than the related drug levorphanol.
Legal status
USA: Refers to Schedule II controlled Substances.
Product Name: Ro4-1539
Other Name(s): furethylnorlevorphanol, Ro4-1539 HCl
IUPAC Name:
(1R,9R,10R)-17-[2-(furan-2-yl)ethyl]-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
17-(2-(Furan-2-yl)ethyl)-3-hydroxymorphinan
7-[(3-Chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-yl)amino]pentanoic Acid S,S-Dioxide-d4 Sodium Salt;
CAS: 27767-85-7
Molar Mass: 337.463 g·mol−1
Molecular Formula: C22H27NO2
InChi Code: InChI=1S/C18H26N2O/c1-3-8-18(21)20-14-13-19(15-16(20)2)12-7-11-17-9-5-4-6-10-17/h4-7,9-11,16H,3,8,12-15H2,1-2H3/b11-7+
InChIKey: YNZFFALZMRAPHQ-CBQOVEMMSA-N
Canonical SMILES: C1CCC23CCN(C(C2C1)CC4=C3C=C(C=C4)O)CCC5=CC=CO5
Formulation: A crystalline solid, Powder

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